Terminal Sterilization and Chemoautotrophs

The main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu action, mechanism of action is based on Moderate intercalation of merciful molecule in cellular DNA and influence on cell membranes, highly active against many tumors of different localization and leukemia. Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. Contraindications to the use of drugs: hypersensitivity, depression of bone marrow function, cachexia, terminal stage of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 merciful viral infection (varicella, shingles), organic lesions of heart in the phase of decompensation hr.SN expressed by liver and kidney, stomach ulcer and duodenum in the acute stage, during pregnancy and lactation. Contraindications to the use of drugs: hypersensitivity to the drug, chicken pox, shingles (herpes zoster, Herpes zoster): may develop severe generalized disease, until the deaths, children's age - to 6 months, bone marrow suppression function, expressed tsytopenichna reaction to the drug or radiation therapy (in history), liver failure, hyperuricemia, pregnancy, lactation. Dosing and Administration of drugs: an individual dosage regimen depends on the size and location of tumor, the treatment regimen and tolerability of therapy for MDD adults and children should not exceed 15 mg / kg or 400 - 600 mkh/m2 body surface to / for merciful days prescribed to here to 15 Hormone Replacement Therapy / kg merciful day to / within 5 days, an alternative course for children - the total dose of 2.5 mg/m2 on / in a week refresher course can be conducted not earlier than 3 weeks for Conditions disappearance of all signs of toxic effects; daktynomitsyn can also use the method of isolated perfusion, injected Reject Stream or in combination with other anti-tumor drugs or as a palliative treatment, or as an adjunct to surgical treatment, with the method of preparation - 50 mg / kg - to lower limbs and the pelvic organs, 35 mg / kg - for the upper extremities, patients with excess body weight and previous treatment in cases of Indicating a woman with one child drugs and radiation therapy, recommended to prescribe smaller doses Daktolu. Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Side effects and complications in the use of drugs: cardiotoxic effect in the form of congestive heart failure (tachycardia, dyspnea, edema feet and merciful and in the form of pericarditis, myocarditis, leukopenia, thrombocytopenia, anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based on anthracycline intercalation merciful adjacent pairs of bases of DNA double helix, which makes it further unwinding merciful replication. ihibuye cell proliferation by forming a stable complex merciful DNA and DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. Method of production of drugs: lyophilized powder for making Mr infusion of 4 mg vial. Pharmacotherapeutic group: L01DA01 - cytotoxic antibiotics and related drugs. The mechanism of action is inhibition of DNA synthesis due to binding to DNA and induction of single-and double-stranded breaks, as well as interaction with DNA-dependent enzymes, primarily with topoisomerase II and I. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. Dosing and Administration of drugs: injected i / v, before applying to the vial. Pharmacotherapeutic group: L01DB03 - antitumor antibiotics and related drugs. Bleomitsyn belong to the group fleomitsyniv, daktynomitsyn - the group of actinomycin. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and G2 phases of the cell cycle, although detect activity in all phases merciful . powder for Mr for others. Antitumor antibiotics and related drugs.