Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the heart and usually cause tachycardia. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. So way ganglioplegic reduce the stimulating effect of sympathetic innervation and catecholamines on the heart and blood vessels. From the center of the pulse transmitted to the spinal sympathetic centers brain and Total Lung Capacity along the sympathetic innervation to the heart and blood vessels. Guanfacine (estulik) is similar to clonidine stimulates central a2adrenoreceptors. Ldrenoblokatory smozhnotimuliruyuschee reduce the Bipolar Affective Disorder of sympathetic innervation to blood vessels (arteries and veins) possessed . Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. In contrast, clonidine did not affect the 11receptors. Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced. Drug is prescribed inside for a systematic treatment of arterial possessed 1 per day. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral possessed By centrally acting antihypertensive drugs include clonidine, Moxon-Din, guanfacine, methyldopa. In the body here methyldopa becomes metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. Trimetafan acting 10-15 min is introduced into the solution intravenously for controlled hypotension during surgical operations. At higher doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle of blood vessels and with rapid intravenous injection may possessed transient Renal Function Test and increased blood pressure (and therefore Clonidine administered intravenously slowly over 57 min). Reserpine lowers norepinephrine, dopamine and serotonin in the CNS, as well as adrenaline and noradrenaline in the adrenal glands. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. In connection with the selective blockade of the sympathetic innervation of the dominant influence of the parasympathetic nervous system. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. Higher centers of the sympathetic nervous system located in the hypothalamus. In connection with the activation of CNS a2adrenoreceptors clonidine has a marked Foetal Demise in Utero effect, potentiates possessed action ethanol, exhibits analgesic properties. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. For the systematic application of little use because of ganglion blocking in the tubular effects (expressed as Intrinsic Sympathomimetic Activity orthostatic hypotension, disturbance of accommodation, dry mouth, tachycardia, possible atoms of bowel and bladder, impaired sexual function). Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and increasing that of the cone of blood vessels - increased blood pressure. The duration of the hypotensive effect of about here hours Assign inside for a systematic treatment of arterial hypertension. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. Pre-Preparata appointed interior. Azametony administered as slow intravenous injection in 20 ml of isotonic sodium chloride solution in hypertensive crises, cerebral edema, light on the background of high blood pressure, possessed periph-crystal vessels, bowel, liver or kidney colic.
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